An artifact known as the “Tablet of Order and Chaos” is shattered into pieces during a skirmish between Spider-Man and Mysterio, causing problems with multiple Marvel Universe realities. Madame Web calls on four versions of Spider-Man from four realities to assist her in bringing the realities back into balance: the Amazing Spider-Man,Spider-Man Noir (a 1930s version of Spider-Man), Spider-Man 2099 (the Spider-Man of a possible future), and a symbiote-bonded Ultimate Spider-Man.